Vitamin A

Vitamin A is a fat-soluble vitamin that comes primarily from animal sources as retinol (preformed vitamin A), a retinoid. The retinoids, a family of structurally related molecules, are essential for vision, reproduction, growth, and maintenance of epithelial tissues. They also play a role in immune function.
Retinoic acid, derived from oxidation of retinol, mediates most of the actions of the retinoids, except for vision, which depends on retinal, the aldehyde derivative of retinol.
A. Structure
The retinoids include the natural forms of vitamin A, retinol and its metabolites (Fig. 1), and synthetic forms (drugs).

Figure 1: Structure of the retinoids.
1. Retinol: A primary alcohol containing a β-ionone ring with an unsaturated side chain, retinol is found in animal tissues as a retinyl ester with long-chain FA. It is the storage form of vitamin A.
2. Retinal: This is the aldehyde derived from the oxidation of retinol. Retinal and retinol can readily be interconverted.
3. Retinoic acid: This is the acid derived from the oxidation of retinal. Retinoic acid cannot be reduced in the body and, therefore, cannot give rise to either retinal or retinol.
4. β-Carotene: Plant foods contain β-carotene (provitamin A), which can be oxidatively and symmetrically cleaved in the intestine to yield two molecules of retinal. In humans, the conversion is inefficient, and the vitamin A activity of β-carotene is only about 1/12 that of retinol.

مواضيع ذات صلة

تخليق الهرمونات الدرقية: مثال آخر لتنوع الهرمونات

تخليق الكاتيكولامينات

تخليق الكالسيترايول

سُبل تخليق الستيروئيدات

Protein Phosphorylation is Extremely Versatile

Reversible Covalent Modification Regulates Key Mammalian Proteins

تحويل الكوليسترول إلى البريغنينولون

تصنيف الهرمونات Classification of Hormones

الطبيعة الكيميائية للمستقبلات Chemical Nature

الحقول الوظيفية في المستقبلات Functional Domains

دور المستقبلات Role of Receptors

الخلية الهدفية والمستقبلات Target Cell & Receptors