Cedrene Synthesis Disconnection at ‘a’
 

G. Stork et.al., (J. Am. Chem. Soc., 77, 1078 (1955); ibid, 83, 3114 (1961)) took advantage of the fact that fused five membered rings would be cis- fused. Such a system would have a crowded ‘concave phase’. These two features formed the basis for Stork’s synthesis of Cedrene. Their synthetic scheme is shown in Figure 1.1. The first alkylation set in motion the steric out come of the remaining steps.

Figure 1.1