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Laboratory approaches to drug testing in DUID cases

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  320

2026-10-28

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Laboratory approaches to drug testing in DUID cases

Drug confirmation The ‘gold standard’ for confirmatory identification of drugs in biological samples is GC-MS, although LC-MS(/MS) methods are being developed which can be considered equally accept able. A clean-up procedure is generally applied to the sample to separate the drug(s) and metabolites from the sample matrix and to concentrate the drugs so that they can be more readily detected and quantified. A commonly applied approach is to exploit the fact that many drugs are basic or acidic. Sample clean-up techniques are manipulated to separate basic drugs from weakly acidic or neutral drugs before each fraction is analysed by GC-MS and/or LC-MS/MS. As different laboratories employ different analytical strategies, details of these will not be given. Detailed strategies can be found in Clarke’s Analysis of Drugs and Poisons (Moffat et al. 2004).